The study utilises a cross-sectional design to investigate obstructive sleep apnoea (OSA) among adult people living with HIV (PLWH).
Study Design
The study utilises a cross-sectional design to investigate obstructive sleep apnoea (OSA) among adult people living with HIV (PLWH). Polysomnography will be conducted to determine the prevalence of OSA, self-reported questionnaires will be administered to validate their use as screening tools for OSA, and associations between OSA, inflammatory markers, and cardiometabolic profiles will be explored.
Study Population
The study will include a cohort of adult PLWH. The selection of the study population will involve up to 100 participants randomly selected from the CHARACTERISE study. Inclusion criteria will include participants who have completed the Berlin Questionnaire during their participation in CHARACTERISE and have access to reliable communication methods (telephone, direct/text messaging). Exclusion criteria will include individuals unable to undergo sleep study procedures, such as complete inability to undergo polysomnography testing due to reasons such as facial anomalies.
Study Sites
The study will be conducted at two sites:
- The Wits Sleep Laboratory, Brain Function Research Group in the School of Physiology, located at Wits Med School, 7 York Road, Parktown, Johannesburg, 2193 This specialised laboratory focuses on sleep research and is equipped with advanced monitoring equipment and is staffed by experts in the field of sleep physiology.
- The Ezintsha-Restonic Sleep Laboratory, situated at 32 Princess of Wales Terrace, Parktown, Johannesburg, 2193. This sleep laboratory is dedicated to studying sleep disorders and promoting sleep health. It is equipped with advanced monitoring technology and staffed by a team of experts in sleep medicine.
By utilising these two esteemed research facilities, the study aims to gather a diverse range of data and insights, contributing to a comprehensive understanding of sleep patterns and related phenomena. The collaboration between these institutions ensures robust research methodologies and facilitates a broader perspective on the subject matter.
Drug(s) to be dispensed at selected site
No drug will be administered in this study.
Study aims
The study aims to comprehensively investigate the prevalence of OSA among PLWH and its association with inflammatory markers and cardiometabolic profiles in a South African context. Specific aims include determining OSA prevalence, validating questionnaires for OSA screening, describing associations between OSA and inflammatory markers, and examining associations between inflammatory markers, cardiometabolic profiles, and OSA diagnosis
Study Objectives
The study aims to:
- Determine the prevalence of OSA among PLWH using polysomnography.
- Validate the effectiveness of self-reported questionnaires (Berlin, STOP-BANG, Epworth Sleepiness Scale) in screening for OSA among PLWH.
- Describe associations between OSA and inflammatory markers within the PLWH cohort.
- Examine associations between inflammatory markers, cardiometabolic profiles, and OSA diagnosis in PLWH
Sample Size
The study will include a cohort of adult PLWH The selection of the study population will involve up to 100 participants randomly selected from the CHARACTERISE study. This sample size has been determined based on feasibility considerations and the available resources for data collection and analysis.
Study duration
12 months
